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Resveratrol, a Potential of Longer Life

Updated: Jan 3, 2021

Resveratrol is a plant polyphenol (a beneficial micronutrient in plants reported by some to improve digestion, brain function, and protects against blood clots, diabetes, neurodegenerative disease, heart disease and some cancers). Per some scientists it can help reverse and or delay aging. Or maybe it thwarts premature aging. So, is this real or pop science?

Here is the general theory. (It may not be correct.) Resveratrol has been reported over and over to rejuvenate by activating specific longevity genes called SIRTUINS, and in particular, the SIRT 1 gene. There are 7 SIRTUIN genes. This SIRT 1 gene is reported to assist in longevity by removing certain bad compounds from the histones (highly alkaline proteins), which the DNA strands wind themselves around.

To know how this works one needs to understand more about the affects of fasting. Fasting has been known to, and said to, extend life and protect the organism from disease. This includes other mammals, not just the human species. It seems that cells may need some physical stress, which they then counter by lengthening their life span. This stress is known as caloric restriction and is said to trigger the SIRT 1 gene.

To date, experiments have shown in fruit fly, worms, rats and rodents, and now monkeys, that longer lives can be achieved by triggering this SIRT 1 gene. It has been further found that resveratrol triggers that same mechanism that stress provides. Thus, thereby lengthening life span. When there is stress, cells use the various compounds of niacin, such as NAD+ and NMN, to also bring this about. (See the references [2 and 3] below and the previous blog on the same.)

It was also found experimentally that resveratrol reduced mortality and neurological functions in rats (1), as well as extending their life.

Now, per some, phenols have also been shown to work on rats better than resveratrol. One super-herb in this, as an example, is sandalwood. It is in our Super Superfood Gold by Himalayan Long Life Botanicals. Pterostilbene is the name of the active compound, and some tote its benefits are more effective than resveratrol. Sandalwood powder however is extraordinarily expensive. But there are other herbs such as turmeric (curcuminoids), which are inexpensive. Included are gingerols from ginger, eugenol from cloves, and coumarin from cinnamon.

The ingredients in the Himalayan Long Life Botanicals Super Superfood Reds were chosen because they are reputed to contain resveratrol or have other alternatives. These ingredients are specifically: cocoa, pomegranate, black grape, beetroot, and moringa, for their resveratrol. They account for 45% of the Reds formula. Those with phenols, which some say do the same or better than resveratrol, are turmeric, ginger, and cinnamon, and they account for a further 12% of the formula. Others such as ashwaganda, rose powder, licorice root powder, and hibiscus have longevity reputations, and account for another 15% of the formula. The remaining ingredients in the Reds are included for their vitamins, minerals, and supply of niacin.

Why are there so many different plants? Some people could say, just have turmeric. Others hail moringa as a miracle tree. There are good arguments for just one or two great superfoods like these. However, it is also been said that if you have mega diets of one vitamin, it can manifest as an apparent deficiency of others. It is not known if this holds true for all trace micronutrients in general, but it seems wise to play safe by increasing the many different types of herbs, plants, and their thousands of plant micronutrients. After all, there are 1300 enzymes in a human cell. And they can create 100,000 chemicals in the body to enable the body to work in all its parts. So, it would behoove us to supply the body with as many nutrient sources as possible. In common sense layman's terms, we might say, eat a balanced nutritional meal for good health.

Resveratrol is reported to empower mitochondria, as so with niacin compounds. This again is why we have it, even if there are phenols some say are better. The mitochondria are micro-cells within our human cell. Mitochondria are said to be the powerhouse within cells. Niacin, along with resveratrol, is said to empower these powerhouses, making them stronger and more efficient in improving the host cell around them.

The next question might be then, why do we believe the Himalayas are the best food source for all these ingredients? That is simple and the logic goes like this. Firstly, there is less atmosphere, and this in theory places more stress on plants to thus produce better resveratrol and phenols. Secondly, there are minerals constantly being pushed to the surface daily as the great Indian and Asian tectonic plates collide. This means these superfoods, truly can be be naturally harvested mega superfoods.

The top illustration above is of Himalayan Knotweed, with Himalayan peaks in the distance, near the Tibetan border, near Bimala's home village.

NOTE: If you are ill, please go to a physician. If on the other hand, you just want good health by a cross selection of good nutrition, our super superfoods by Himalayan Long Life Botanicals are available for you.

More information:

  1. Resveralogues: From Novel Ageing Mechanisms to New Therapies? Faragher RGA, Ostler EL.Gerontology. 2020 Jan 8:1-7. doi: 10.1159/000504845. [Epub ahead of print] Review. PMID: 31914446 Similar articles

  2. Control of Inflammation by Calorie Restriction Mimetics: On the Crossroad of Autophagy and Mitochondria. Gabandé-Rodríguez E, M Gómez de Las Heras M, Mittelbrunn M.Cells. 2019 Dec 28;9(1). pii: E82. doi: 10.3390/cells9010082. Review. PMID: 31905682 Free PMC Article Similar articles

  3. T-cell activation-inhibitory assay: a proposed novel method for screening caloric restriction mimetics. Iura S, Ojima Y, Amakura Y, Yoshimura M, Sawamoto A, Okuyama S, Furukawa Y, Nakajima M.Biomed Res. 2019;40(6):235-241. doi: 10.2220/biomedres.40.235. PMID: 31839667 Free Article Similar articles

  4. The Role and Mechanism of SIRT1 in Resveratrol-regulated Osteoblast Autophagy in Osteoporosis Rats. Yang X, Jiang T, Wang Y, Guo L.Sci Rep. 2019 Dec 5;9(1):18424. doi: 10.1038/s41598-019-44766-3. PMID: 31804494 Free PMC Article Similar articles

  5. Mechanisms of aging and potential role of selected polyphenols in extending healthspan. Russo GL, Spagnuolo C, Russo M, Tedesco I, Moccia S, Cervellera C.Biochem Pharmacol. 2020 Mar;173:113719. doi: 10.1016/j.bcp.2019.113719. Epub 2019 Nov 21. Review. PMID: 31759977 Similar articles

  6. [Comparative analysis of experimental data about the effects of various polyphenols on lifespan and aging.] Panchenko AV, Tyndyk ML, Fedoros EI, Maydin MA, Semenov AL, Gubareva EA, Golubev AG, Anisimov VN.Adv Gerontol. 2019;32(3):325-330. Russian. PMID: 31512417 Similar articles

  7. Effect of the Resveratrol Rice DJ526 on Longevity. Islam MS, Jin YY, Chung HJ, Kim HJ, Baek SH, Hong ST.Nutrients. 2019 Aug 5;11(8). pii: E1804. doi: 10.3390/nu11081804. PMID: 31387244 Free PMC Article Similar articles

  8. Pharmacological basis and new insights of resveratrol action in the cardiovascular system. Cheng CK, Luo JY, Lau CW, Chen ZY, Tian XY, Huang Y.Br J Pharmacol. 2020 Mar;177(6):1258-1277. doi: 10.1111/bph.14801. Epub 2019 Dec 8. Review. PMID: 31347157 Similar articles

  9. Genetic background, epigenetic factors and dietary interventions which influence human longevity. Costa D, Scognamiglio M, Fiorito C, Benincasa G, Napoli C.Biogerontology. 2019 Oct;20(5):605-626. doi: 10.1007/s10522-019-09824-3. Epub 2019 Jul 15. Review. PMID: 31309340 Similar articles

  10. Some naturally occurring compounds that increase longevity and stress resistance in model organisms of aging. Gómez-Linton DR, Alavez S, Alarcón-Aguilar A, López-Diazguerrero NE, Konigsberg M, Pérez-Flores LJ.Biogerontology. 2019 Oct;20(5):583-603. doi: 10.1007/s10522-019-09817-2. Epub 2019 Jun 11. Review. PMID: 31187283 Similar articles

  11. Evolvement of nutraceutical onion plants engineered for resveratrol biosynthetic pathway. Naini R, Pavankumar P, Prabhakar S, Kancha RK, Rao KV, Reddy VD.Plant Cell Rep. 2019 Sep;38(9):1127-1137. doi: 10.1007/s00299-019-02432-y. Epub 2019 Jun 1. PMID: 31154513 Similar articles

  12. Molecular docking analysis of imine stilbene analogs and evaluation of their anti-aging activity using yeast and mammalian cell models. Naini R, Chikati R, Vudem DR, Kancha RK.J Recept Signal Transduct Res. 2019 Feb;39(1):55-59. doi: 10.1080/10799893.2019.1605529. Epub 2019 May 28. PMID: 31132911 Similar articles

  13. Molecular and Cellular Characterization of SIRT1 Allosteric Activators. Schultz MB, Rinaldi C, Lu Y, Amorim JA, Sinclair DA.Methods Mol Biol. 2019;1983:133-149. doi: 10.1007/978-1-4939-9434-2_8. PMID: 31087296 Free PMC Article Similar articles

  14. The Resveratrol Rice DJ526 Callus Significantly Increases the Lifespan of Drosophila (Resveratrol Rice DJ526 Callus for Longevity). Khan M, Park S, Kim HJ, Lee KJ, Kim DH, Baek SH, Hong ST.Nutrients. 2019 Apr 29;11(5). pii: E983. doi: 10.3390/nu11050983. PMID: 31036789 Free PMC Article Similar articles

  15. The role of sirtuin 1 and its activator, resveratrol in osteoarthritis. Deng Z, Li Y, Liu H, Xiao S, Li L, Tian J, Cheng C, Zhang G, Zhang F.Biosci Rep. 2019 May 10;39(5). pii: BSR20190189. doi: 10.1042/BSR20190189. Print 2019 May 31. Review. PMID: 30996115 Free PMC Article Similar articles

  16. Frailty index as a biomarker of lifespan and healthspan: Focus on pharmacological interventions. Palliyaguru DL, Moats JM, Di Germanio C, Bernier M, de Cabo R.Mech Ageing Dev. 2019 Jun;180:42-48. doi: 10.1016/j.mad.2019.03.005. Epub 2019 Mar 26. Review. PMID: 30926563 Similar articles

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  18. Health Benefits of Anti-aging Drugs. Piskovatska V, Strilbytska O, Koliada A, Vaiserman A, Lushchak O.Subcell Biochem. 2019;91:339-392. doi: 10.1007/978-981-13-3681-2_13. Review. PMID: 30888659 Similar articles

  19. Drugs targeting SIRT1, a new generation of therapeutics for osteoporosis and other bone related disorders? Zainabadi K.Pharmacol Res. 2019 May;143:97-105. doi: 10.1016/j.phrs.2019.03.007. Epub 2019 Mar 9. Review. PMID: 30862606 Similar articles

  20. Resveratrol alleviates chemotherapy-induced oogonial stem cell apoptosis and ovarian aging in mice. Wu M, Ma L, Xue L, Ye W, Lu Z, Li X, Jin Y, Qin X, Chen D, Tang W, Chen Y, Hong Z, Zhang J, Luo A, Wang S.Aging (Albany NY). 2019 Feb 14;11(3):1030-1044. doi: 10.18632/aging.101808. [Epub ahead of print] PMID: 30779707 Free PMC Article Similar articles

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